The patient is a 68 year old man with a slowly enlarging nodule of the scalp. Excisional biopsy is performed.
Diagnosis: Cutaneous lymphadenoma
The cutaneous lymphadenoma is a rare benign neoplasm of uncertain histogenesis, although it is generally considered to be a variant of trichoblastoma. This lesion has also been reported under the names adamantinoid trichoblastoma and lymphoepithelial tumor of the skin. It typically occurs as a solitary non ulcerated and slowly enlarging nodule on the head.
References: Alsadhan A, et al. Cutaneous lymphadenoma. J Am Acad Dermatol 49(6):1115-6. 2003.
Betti R, Alessi E. Nodular trichoblastoma with adamantinoid features. Am J Dermatopathol 18(2):192-195, 1996.
Diaz-Cascajo C, Borghi S, Rey-Lopez A, Carretero-Hernandez G. Cutaneous Lymphadenoma: A peculiar variant of nodular trichoblastoma. Am J Dermatopathol 18(2):186-191, 1996.
Santa Cruz DJ, Barr RJ, Headington JT. Cutaneous lymphadenoma. Am J Surg Pathol 15(2): 101-110, 1991.
McNiff JM, Eisen RN, Glusac EJ. Immunohistochemical comparison of cutaneous lymphadenoma, trichoblastoma, and basal cell carcinoma: support for classification of lymphadenoma as a variant of trichoblastoma. J Cutan Pathol 26: 119-124, 1999.